在大型社区样本中,Covid-19后的认知和记忆
Adam Hampshire1, Adriana Azor1, Christina Atchison1
1From the Department of Brain Sciences (A.H., A.A., W.T., V.G.), MRC Centre for Environment and Health (M.C.-H., P.E.), School of Public Health (C.A., E.C., A.L., C.A.D., M.C.-H., H.W., P.E.), and the Department of Infectious Disease (G.S.C.), Imperial College London, the National Institute for Health Research Imperial Biomedical Research Centre (C.A., G.S.C., E.C., A.L., H.W., P.E.), the Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (P.J.H.), Imperial College Healthcare NHS Trust (G.S.C., H.W., P.E.), Health Data Research U.K. London at Imperial (P.E.), and U.K. Dementia Research Institute at Imperial (P.E.), London, and the Nuffield Department of Clinical Neurosciences (M.H.), the Departments of Experimental Psychology (M.H.) and Statistics (C.A.D.), and the Pandemic Sciences Institute (C.A.D.), University of Oxford, Oxford - all in the United Kingdom.
在2019年冠状病毒病 (Covid-19) 后的认知缺陷是可测量的,特别是持续的症状. 从Covid-19中恢复可能导致轻微的认知障碍,长期影响仍然不确定.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在2019年冠状病毒疾病 (Covid-19) 之后,经常报告认知症状.
- 在Covid-19后,客观可衡量的认知缺陷的存在和持续时间尚未得到充分证实.
研究的目的:
- 在COVID-19感染后对个人进行客观可测的认知缺陷的调查.
- 为了确定持续的症状是否与认知障碍相关.
- 评估不同Covid-19变种和住院治疗对认知功能的影响.
主要方法:
- 在英格兰,对112,964名从Covid-19中康复或没有确诊感染的参与者进行了在线认知评估.
- 全球认知分数在八项任务中估计,重点是执行功能和记忆.
- 用多重回归和倾向分数匹配分析来比较群体之间的认知表现.
主要成果:
- 与没有Covid-19的人相比,在Covid-19后出现未解决的持续症状的参与者表现出更大的全球认知缺陷.
- 在感染早期SARS-CoV-2变种 (例如B.1.1.7) 和住院后,认知缺陷更加明显.
- 记忆,推理和执行功能任务显示出最大的缺陷,与自我报告的脑雾或记忆问题存在弱相关性.
结论:
- 在Covid-19之后解决的持续症状与类似于短期Covid-19的认知功能有关,Covid-19本身显示出小的缺陷.
- 认知缺陷的长期持续及其临床意义需要进一步调查.
- 在研究期间没有报告任何不良事件.
相关概念视频
Cognitive Development During Adulthood
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Role of Cerebellum and Prefrontal Cortex in Memory
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Cognitivism
Previously dominated by behaviorism, which prioritized observable behaviors and largely ignored mental processes, psychology transformed in the 1950s. Cognitive psychologists argue that understanding how we think and process...
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...


