随着时间的推移,艾滋病毒感染者的动脉样硬化心血管疾病风险发生变化
Weisi Chen1, Kathy Petoumenos1, Agus Somia2
1Kirby Institute, UNSW Sydney, Sydney, Australia.
The Journal of antimicrobial chemotherapy
|February 28, 2024
概括
动脉样硬化心血管疾病 (ASCVD) 的风险增加超过5年的抗逆转录病毒疗法 (ART) 在与艾滋病毒 (PLHIV) 感染者. 这种ASCVD风险的增加在不同艾滋病毒亚种群中是一致的,突出了重大公共卫生挑战.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染者 (PLHIV) 患有动脉样硬化心血管疾病 (ASCVD) 的风险增加.
- 了解抗逆转录病毒治疗 (ART) 的PLHIV中ASCVD风险的时间变化对于有效管理至关重要.
- 现有的关于不同PLHIV种群中ASCVD风险进展的数据有限.
研究的目的:
- 为了描述随着时间的推移,与艾滋病毒感染者 (PLHIV) 开始治疗的动脉样硬化心血管疾病 (ASCVD) 风险的变化.
- 分析PLHIV人群中不同的人口和临床子组的ASCVD风险趋势.
主要方法:
- 利用来自TREAT亚洲艾滋病毒观察数据库 (TAHOD) 和澳大利亚艾滋病毒观察数据库 (AHOD) 的数据.
- 使用D:A:D方程计算的5年ASCVD风险,用于18岁以上的个体,没有先前的ASCVD病史,在ART启动5年内完成风险因素数据.
- 包括3368名成年人,分析了因艾滋病毒暴露,种族/种族和CD4数量最低点而分层的风险变化.
主要成果:
- 整体ASCVD风险从ART开始时的0.84%增加到ART治疗5年后的1.34%.
- 这种ASCVD风险的增加在艾滋病毒暴露 (异性恋者,与男性发生性关系的男性,注射毒品的人),种族/种族 (高加索人,亚洲人) 和CD4细胞计数 (<200和≥200细胞/毫米3) 定义的亚群中一致观察到.
- 在这些不同的群体中,ASCVD风险增加的速度是相似的.
结论:
- 这些发现强调了艾滋病毒感染者 (PLHIV) 中ASCVD风险的负担越来越大.
- 对于减轻PLHIV中ASCVD风险的干预措施非常需要.
- 干预措施必须在广泛的艾滋病毒亚群中有效,以解决这一公共卫生问题.
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