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Updated: Jul 2, 2025

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
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人环素通过共享的基因表达反应特征签名诱导心脏毒性

E Renee Matthews1, Omar D Johnson2, Kandace J Horn3

  • 1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.

PLoS genetics
|February 28, 2024
PubMed
概括

在乳腺癌治疗中使用的拓糖酶II抑制剂 (TOP2i) 可以导致心脏损伤. 这项研究发现,TOP2i诱导心肌细胞的共同基因表达变化,影响的处理,并揭示了对这些心脏毒药物反应的个体遗传变异.

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