一种可吞的自动推进装置用于肠道复苏
Shriya S Srinivasan1,2,3, Julien Dosso2, Hen-Wei Huang1,2,3
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science robotics
|February 28, 2024
概括
一种新的可吞设备INSPIRE使用电刺激来恢复肠道周位心. 这项技术有效地治疗手术后阴茎 (POI) 和其他运动障碍,提供了一个有前途的非侵入性治疗选择.
科学领域:
- 胃肠病学 胃肠病学
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 手术后大肠 (POI) 延长了住院时间,缺乏有效的治疗方法.
- 目前对POI的支持性疗法往往不足,并导致副作用.
- 现有的电刺激研究显示了肠道节拍的潜力,但缺乏有针对性的设备.
研究的目的:
- 开发和验证用于肠道复苏的可吞自动推进装置 (INSPIRE).
- 为了恢复周平静,并使用光线电刺激治疗POI.
- 为了评估设备在正常,抑郁和化学诱导的阴茎模型中的有效性.
主要方法:
- 优化了INSPIRE设备的机械,材料和电气设计参数.
- 在猪模型中验证了设备部署,电接触,自动推进,安全和降解.
- 在各种阴道模型中比较INSPIRE对肠道运动的影响.
主要成果:
- 在麻醉动物中,肠道收缩改善了44%,在化学诱导的肠中,改善了140%.
- 通过INSPIRE,过境时间从8.6天 (对照) 减少到2.5天.
- 通过INSPIRE进行的光线电刺激有效地恢复了围静活动.
结论:
- 该INSPIRE设备通过光线电刺激有效地恢复肠周平静.
- 这种非侵入性技术为结核和其他胃肠机动性障碍提供了有前途的治疗解决方案.
- 在临床前模型中,INSPIRE 显示了运动能力的显著改善和通过时间的减少.
相关概念视频
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
132
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
132
Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145
Enteral Nutrition I: Orogastric and Nasogastric Feeding
281
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
281


