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Updated: Jul 2, 2025

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在人类细胞中复制基三损伤的复制研究

Jun Wu1, Jiabin Wu2, Garrit Clabaugh1

  • 1Department of Chemistry, University of California Riverside, Riverside, California 92521-0403, United States.

Chemical research in toxicology
|February 28, 2024
PubMed
概括

基三 (基-PTE) DNA 损伤中等缓慢复制,但被精确绕过. 特定的转化合成聚合酶 (Pol η,Pol ζ,Pol κ) 对于绕过这些DNA损伤类型至关重要.

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Translesion DNA Polymerases02:10

Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
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