便中calprotectin和myeloperoxidase在预测炎症性肠病结果中的比较
A Swaminathan1,2, G M Borichevsky3, C M Frampton1
1Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
便生物标志物,如便calprotectin (fCal) 和便髓氧化酶 (fMPO),有效预测复杂的炎症性肠病 (IBD) 过程. 这些中性粒细胞生物标志物为IBD管理提供了超越临床症状和C-反应蛋白 (CRP) 的宝贵见解.
科学领域:
- 胃肠病学 胃肠病学
- 临床生物标志物 临床生物标志物
- 炎症性肠病 (IBD) 研究研究
背景情况:
- 生物标志物被探索为炎症性肠病 (IBD) 的治疗点.
- 中性粒细胞生物标志物,便calprotectin (fCal) 和便myeloperoxidase (fMPO) 对IBD并发症的预测价值尚未得到充分确立.
研究的目的:
- 调查便calprotectin (fCal) 和便髓氧化酶 (fMPO) 在预测复杂的炎症性肠病 (IBD) 过程中的有用性.
- 将便生物标志物的预测性能与临床指数和C反应蛋白 (CRP) 的预测性能进行比较.
主要方法:
- 一项长达24个月的前性研究跟踪了171名IBD参与者 (99名克罗恩病患者,90名女性).
- 复杂的IBD过程是由皮质类固醇使用,药物升级或IBD相关住院/手术定义的.
- 接收器运行特征曲线 (AUROC) 下的面积和多变量后勤回归分析了基线fCal,fMPO,临床症状和CRP.
主要成果:
- 基线fCal (250μg/g) 和fMPO (12μg/g) 显著预测了复杂的IBD过程 (AUROC=0.77).
- 调整后勤回归显示fCal (OR=7.85) 和fMPO (OR=4.43) 是独立的预测因素,表现优于C反应蛋白 (CRP).
- 基线CRP,fCal/fMPO和临床症状的组合在识别复杂IBD病例时提供了最高的精度.
结论:
- 便生物标志物fCal和fMPO是炎症性肠病 (IBD) 的不良结果的独立预测剂.
- 这些便生物标志物作为管理IBD的常规临床评估的有价值的附加剂.
- 来自中性粒细胞的便生物标志物增强了复杂IBD过程的预测.
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