呼吸道病毒感染对移植接受者的影响
Hannah Bahakel1, Alpana Waghmare2, Rebecca Pellet Madan3
1Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Journal of the Pediatric Infectious Diseases Society
|February 28, 2024
概括
呼吸道病毒感染 (RVI) 对儿科移植接受者构成重大风险,增加了发病率和死亡率. 了解RVI流行病学和结果对于开发有效的预防和治疗策略至关重要.
科学领域:
- 儿科血液学/瘤学
- 传染性疾病 传染性疾病
- 移植手术 移植手术
背景情况:
- 呼吸道病毒感染 (RVI) 是在接受血造干细胞移植 (HCT) 或固体器官移植 (SOT) 的儿童中疾病和死亡的主要原因.
- 这些感染可能会导致严重的并发症,如细菌/真菌性肺炎,慢性移植问题,以及儿科移植患者的移植失败.
- 使用先进的分子诊断的最新研究改善了我们对这种脆弱人群的RVI模式和结果的理解.
研究的目的:
- 审查有关RVI在小儿SOT和HCT接受者的流行病学和结果的当前知识.
- 描述在移植患者中识别RVI的诊断方法.
- 讨论管理方面的进展,疫苗接种,来自供体的RVI风险,以及移植时间的考虑.
主要方法:
- 本综述综合了多中心回顾性和前性研究的发现.
- 它结合了使用当代分子诊断技术的研究数据.
- 该审查还基于既定的临床指南和专家的共识.
主要成果:
- 在儿科HCT和SOT接受者中,RVI显著影响了发病率和死亡率.
- 通过分子测试进行早期和准确的诊断对于及时干预至关重要.
- 不断发展的管理策略和预防性疫苗正在改善结果,尽管仍然存在挑战.
结论:
- 儿科移植接收者面临RVI的严重威胁,需要进行警监测和主动管理.
- 持续研究和实施先进的诊断,疫苗和治疗方案对于减少RVI相关并发症和改善长期生存至关重要.
- 在移植前和移植后仔细考虑RVI状态是很重要的,以优化患者安全和移植成功.
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