相关实验视频
Updated: Jul 2, 2025

07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
4.0K
微生物组和儿科移植
Caitlin W Elgarten1,2, Elisa B Margolis3,4, Matthew S Kelly5
1Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Journal of the Pediatric Infectious Diseases Society
|February 28, 2024
概括
人类微生物群通过影响感染风险和免疫反应来影响移植成功. 了解微生物组的变化和疗法可以改善结果,特别是在儿科移植中.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 移植科学 移植科学
背景情况:
- 人类微生物群,包括体内的微生物群落,越来越多地被认为对宿主健康和疾病的影响.
- 微生物组在殖民抵抗中的作用影响了移植后的感染风险,包括多抗药生物体感染.
- 微生物组通过直接相互作用和代谢物产生来调节宿主免疫力,影响免疫耐受性,移植对宿主疾病和移植排斥.
研究的目的:
- 提供对微生物组在造血细胞和固体器官移植中的作用的全面审查.
- 检查移植过程中微生物组变化的驱动因素.
- 探索基于微生物组的疗法的潜力,以改善儿科移植结果.
主要方法:
- 文献综述综合了当前关于微生物组和移植的证据.
- 对调查移植受体微生物组转移的研究进行分析.
- 评估新兴的基于微生物组的治疗策略.
主要成果:
- 微生物组显著影响移植后感染风险和免疫反应.
- 微生物组失调与不良移植结果有关,包括排斥和GvHD.
- 在移植过程中观察到特定的微生物变化,受各种因素的影响.
结论:
- 微生物组是造血细胞和固体器官移植结果的关键因素.
- 向微生物组调制为改善移植成功提供了有希望的治疗途径.
- 进一步研究基于微生物组的干预措施至关重要,特别是对于儿科患者.
相关概念视频
Tissue Transplantation
366
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
366
Bone Marrow Sampling and Transplants
330
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
330
Anatomy of the Intestines
71.9K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.9K
What is Monogastric Digestion?
71.2K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.2K

