抓捕犬对重度难治性患者的有效性:来自EPISODE研究的结果
Valérie van Hezik-Wester1, Saskia de Groot1, Tim Kanters1
1From the Erasmus School of Health Policy & Management (ESHPM) (V.H.-W., S.G., T.K., W.B., I.C.R., M.V., J.E.), Institute for Medical Technology Assessment (iMTA) (V.H.-W., S.G., T.K., I.C.R., M.V.), and Erasmus Centre for Health Economics Rotterdam (EsCHER) (V.H.-W., S.G., T.K., W.B., I.C.R., M.V., J.E.), Erasmus University Rotterdam; Academic Center for Epileptology Kempenhaeghe (L.W.), Heeze; Stichting Epilepsie Instellingen Nederland (SEIN) (J.A.), Heemstede; Leiden University Medical Center (S.C.); Huygens & Versteegh (M.V.), Zwijndrecht, the Netherlands.
发作犬显著降低了发作频率,并增加了严重耐药性 (PSRE) 患者的无发作日. 这些狗还改善了与健康有关的生活质量,提供了不仅仅是减少发作的好处.
科学领域:
- 神经学 神经学
- 临床试验 临床试验
- 动物辅助干预 动物辅助干预
背景情况:
- 严重的医疗耐药性 (PSRE) 显著影响患者的生活质量.
- 抓捕犬在管理PSRE方面的有效性仍然是研究领域.
研究的目的:
- 评估狗对患有重度抗药性 (PSRE) 患者的益处.
主要方法:
- 一个阶段随机对照试验进行,成年人每天或每周有发作.
- 参与者在最初一段时间的通常护理后,得到了一只发作犬.
- 发作频率,无发作日,发作严重程度,与健康相关的生活质量 (HRQoL) 和幸福感是主要和次要结局.
主要成果:
- 随着狗干预,每28天的发作频率下降了3.1%.
- 发现了无日数的增加和通用HRQoL (EQ-5D-5L) 的改善.
- 没有发现对发作严重程度 (NHS3) 的显著影响,其他生活质量指标的温和改善.
结论:
- 发作犬有效地减少了PSRE患者的发作频率,并增强了PSRE患者的无发作日.
- 对通用HRQoL的积极影响表明,好处超出了控制范围.
- 在某些情况下,早期停止治疗表明发作犬可能不适合所有PSRE患者,因此需要进一步研究.
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