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索科特拉斯特硫酸盐通过抑制JAK活动来抑制IFN-γ诱导的PD-L1表达

Xiaobo Wang1, Wenlong Xu1, Zengyiyi Wang2

  • 1Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 131 Dong-An Road, Shanghai 200032, People's Republic of China.

Journal of natural products
|February 28, 2024
PubMed
概括

海洋天然产物硫酸索克特拉斯特 (SKS) 通过准JAK/STAT信号来抑制PD-L1的表达. 这种化合物使瘤细胞对杀死T细胞敏感,为新型癌症免疫治疗剂提供了潜力.

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