肌酸补充剂用于优化功能障碍患者的身体功能:系统性审查和元分析
Thomas W Davies1,2, Naomi Watson1,2, James J Pilkington3
1William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
JPEN. Journal of parenteral and enteral nutrition
|February 28, 2024
概括
肌酸补充剂在危险人群中有望改善身体功能,肌肉力量和肌肉质量. 需要进一步的高质量试验来证实这些对功能下降的个体的好处.
科学领域:
- 运动科学 运动科学 运动科学
- 营养生物化学 营养生物化学
- 老年学是一门学科.
背景情况:
- 肌酸补充剂对提高患有残疾风险的个体身体功能的有效性仍然不确定.
- 面临风险的人群包括老年人和患有慢性疾病的人群,在这些情况下,维持身体功能至关重要.
研究的目的:
- 系统地评估肌酸补充剂对风险人群身体功能功效的有效性.
- 综合来自随机对照试验 (RCT) 关于肌酸对身体和肌肉功能以及身体组成的影响的证据.
主要方法:
- 在主要数据库 (MEDLINE,EMBASE,Cochrane Library,CINAHL) 进行了全面的文献搜索,截至2022年11月.
- 包括在内的RCT比较了老年人和患有慢性疾病的成年人的肌酸补充与安慰剂.
- 主要结局是身体功能 (坐立测试),通过随机效应元分析和贝叶斯方法分析;次要结局包括肌肉力量和身体组成.
主要成果:
- 分析了33个RCT,共1076名参与者.
- 肌酸补充剂显著改善了坐站表现 (SMD 0.51),上半身强度 (SMD 0.25),手握强度 (SMD 0.23) 和瘦组织质量 (MD 1.08 公斤).
- 肌酸改善身体功能的概率为66.7%,但总体证据质量低至非常低,因为偏差风险很高.
结论:
- 补充肌酸似乎可以提高坐站表现,肌肉功能和瘦体质量.
- 高质量的前性RCT对于验证这些发现和证实肌酸在风险人群中的益处至关重要.
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