鲁布斯西部及其对抗癌症的生物活性化合物:从分子机制到翻译进步
Guanru Wang1, Hengpei Su2, Zijian Guo1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section of Ren Min Nan Rd., Chengdu 610041, China; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section of Ren Min Nan Rd., Chengdu 610041, China.
概括
黑色大 (BRB) 显示出作为癌症植物疗法的巨大潜力,通过各种机制抑制瘤生长和转移,并具有最小的副作用. 在癌症治疗中,BRB的局部应用已经证明了临床益处.
科学领域:
- 植物疗法 植物疗法
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 癌症是全球主要的死亡原因,治疗耐药性日益增加.
- 使用天然化合物的植物疗法为癌症预防和治疗提供了一个有前途的替代方案.
- 黑色大 (BRB,Rubus Occidentalis) 含有丰富的生物活性化合物,如酸和酸,具有抗癌潜力.
研究的目的:
- 审查关于BRB在癌症预防和治疗中的作用的研究.
- 分析BRB的有效成分,代谢途径和抗癌机制.
- 评估BRB作为一种潜在的植物治疗剂.
主要方法:
- 在Ovid MEDLINE,EMBASE,Web of Science和CENTRAL数据库中进行全面的文献搜索.
- 选了767篇文章的标题和摘要,并对符合条件的研究进行了全文审查.
- 包括73篇论文,其中63篇专注于抗癌机制,10篇关于临床试验.
主要成果:
- BRB通过准参与DNA修复,表观遗传学,细胞循环调节,细胞亡和能量代谢的途径,影响多种癌症特征.
- BRB减少DNA损伤,增强瘤抑制基因表达,诱导细胞循环停止,并促进亡和热亡.
- 尽管生物可用性有限,但BRB抑制糖解和血管生成,改善瘤微环境,并通过局部应用证明临床益处.
结论:
- 黑色树表现出各种抗癌机制,抑制癌症的发病,进展和转移,副作用最小.
- 在癌症治疗中,BRB是植物疗法的有希望的候选者.
- 局部配方的BRB显示显著的临床疗效.
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