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许多直接向消费者销售的犬类遗传测试可以识别纯种犬的品种

Halie M Rando^1,2, Kiley Graim³, Greg Hampikian⁴

¹1Department of Biomedical Informatics, Anschutz School of Medicine, University of Colorado, Aurora, CO.

Journal of the American Veterinary Medical Association

|February 28, 2024

概括

用户提交的照片可以影响直接向消费者 (DTC) 遗传测试对狗的品种预测. 一些测试和神经网络倾向于照片而不是DNA,突出了犬类遗传祖先分析的挑战.

科学领域:

狗的遗传学狗的遗传学
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

直接向消费者 (DTC) 基因测试对于寻求品种祖先信息的物主人来说越来越受欢迎.
DTC遗传测试的准确性可能受到各种因素的影响,包括数据解释和潜在的偏见.

研究的目的:

评估用户提供的照片对DTC对狗的基因测试服务的品种祖先预测准确性的影响.
为了比较多家DTC遗传测试公司在识别犬种祖先方面的表现.

主要方法:

来自12只纯种犬的6个口腔抽样被提交给六个不同的DTC遗传测试公司.
在样本注册过程中,对一半的狗包括狗的照片,对另一半使用交换照片.
卷积神经网络 (CNN) 被用作控制,以评估仅基于照片的品种预测.

主要成果:

在六项DTC测试中,有五项一致确定了狗的注册品种.
一个DTC测试和CNN不准确地预测了品种,表明他们更喜欢提交的照片而不是DNA证据.
在不同测试中对品种祖先预测的显著变化凸显了犬类遗传分析的挑战,即使是纯种犬.

结论:

兽医可能需要为客户解释DTC遗传测试结果,需要了解他们的局限性.
这项研究为评估消费级犬类遗传检测工具包的可靠性提供了有价值的背景.
这些发现强调了DTC对狗的遗传祖先预测中可能存在的摄影偏差.

关键词:

这种品种的祖先.狗的遗传学狗的遗传学深度学习是一种深度学习.直接向消费者提供服务.基因检测基因检测是指基因检测.

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