化的纳米凝输送系统:不止一个"一个尺寸适合所有"的溶液
Sylvia N Kłodzińska1, Qiuyu Wang1, Natalia Molchanova2
1Center for Biopharmaceuticals and Biobarriers in Drug Delivery (BioDelivery), Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Journal of colloid and interface science
|February 28, 2024
概括
的特性显著地影响了氨酸纳米凝中的封装. 疏水性会导致释放速度较慢,而性会导致快速释放,影响药物输送应用.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 基于氨酸的纳米凝是用于治疗的有希望的可生物降解载体.
- 了解-纳米凝相互作用对于优化药物输送系统至关重要.
研究的目的:
- 调查结构 (电荷,疏水性) 和其在酸纳米凝中的封装之间的关系.
- 评估性质对纳米凝特性,结构,释放动力学和体外活性的影响.
主要方法:
- 微流体被用来组装带有的纳米凝.
- 动态光散射,激光多普勒电泳和小角度中子散射被用来描述纳米凝的大小和表面特性.
- 评估了二次结构的变化,释放谱和体外抗菌活性.
主要成果:
- 疏水性表现出更强的结合,内部定位,从而产生具有更光滑表面和更慢释放的球形纳米凝.
- 定位在纳米凝表面的阳离子和性,导致更的结构和快速,完整的释放.
- 纳米凝的特性和释放与的电荷和性直接相关.
结论:
- 的特性极大地决定了封装效率和释放动力学从酸纳米凝.
- 根据治疗性特征量身定制纳米凝设计对于有效的药物输送至关重要.
- 这些发现突出了纳米凝的多功能性,但强调了对特异性优化的需求.
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