唾液腺细胞学中的陷
Carla Saoud1, Gabrielle E Bailey1, Ashleigh Graham1
1Division of Cytopathology, Department of Pathology, The Johns Hopkins Medical Institution, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Acta cytologica
|February 28, 2024
概括
通过细针吸血 (FNA) 诊断唾液腺病变是具有挑战性的,因为重叠的特征. 免疫组织化学和分子测试等辅助研究对于准确的诊断和适当的患者管理至关重要.
科学领域:
- 细胞病理学 细胞病理学
- 手术病理学手术病理学
- 头部和部瘤学 头部和部瘤学
背景情况:
- 唾液腺病变在细针吸收 (FNA) 上存在诊断挑战,原因是细胞形态多样化和不常见的性质.
- 良性和恶性实体之间的重叠特征,以及转移性和退行性变化,使准确的FNA解释复杂化.
- 准确的诊断对于指导患者管理和避免不必要的激进治疗至关重要.
研究的目的:
- 在FNA材料上审查常见的唾液腺瘤及其细胞形态特征.
- 突出了唾液腺细胞学中的诊断陷和挑战.
- 讨论辅助研究在提高诊断准确性的有用性.
主要方法:
- 对常见的唾液腺瘤及其在FNA上的细胞形态特征的综述.
- 分析由细胞形态重叠和非新发性变化引起的诊断陷.
- 评估免疫组织化学和分子研究作为辅助诊断工具的作用.
主要成果:
- 在良性和恶性唾液腺病变之间存在许多细胞形态重叠,导致潜在的误解.
- 形质变化,囊性和退行性变化进一步导致诊断困境.
- 辅助研究,包括免疫组织化学 (如PLAG1,CD117,DOG1) 和分子变化 (如MYB,MAML2,ERBB2/HER2),有助于区分具有挑战性的病例.
结论:
- 唾液腺细胞学充满了由于显著的细胞形态重叠和混因素的诊断陷.
- 熟悉细胞形态学和辅助研究的战略应用对于改善诊断产量至关重要.
- 精确的FNA诊断唾液腺病变对于适当的患者管理和预防过度治疗至关重要.
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