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神经病痛中的BDNF;无法理解的罪祸首

Peter A Smith¹

¹Neuroscience and Mental Health Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.

|February 28, 2024

概括

大脑衍生神经营养因子 (BDNF) 对男性神经病痛至关重要,而不是女性. 来自微质的BDNF增加了神经元刺激性,导致疼痛和相关情绪障碍.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
分子生物学分子生物学

背景情况:

神经病变性疼痛涉及神经元刺激能力的复杂变化.
大脑衍生神经营养因子 (BDNF) 涉及到疼痛信号传递.
性差异存在于疼痛感知和机制.

研究的目的:

阐明BDNF在神经病痛中的作用,特别是性别依赖的机制.
研究BDNF在疼痛通路中的细胞来源和下游影响.
探索BDNF在上脊椎疼痛处理和并发性疾病中的参与.

主要方法:

从受伤的神经中释放的分子介质的分析.
研究微质激活和纯能受体表达 (P2X4).
评估BDNF对神经元刺激性和突触功能的影响.
检查对GABAergic抑制和NMDA受体活性的影响.
探索由天体细胞衍生的细胞因子释放.
在 thalamus,皮质和半边缘系统疼痛处理的评估.

主要成果:

在男性中,BDNF对于神经病痛的发作和维持至关重要,但在女性中却不是如此.
微质细胞被CSF-1激活并表达P2X4受体,释放BDNF.
微质BDNF增强激发性并减少抑制性神经元信号传递,改变化物梯度,并增加NMDA受体功能.
此外,BDNF还促进星球细胞释放的促炎性细胞因子,有助于背部角的过度兴奋.
周围神经损伤会影响上脊柱结构,有证据表明男性的微质BDNF参与.

结论:

微质衍生BDNF通过增加神经元刺激性,是男性神经病痛的关键驱动因素.
疼痛机制的性别差异很明显,T淋巴细胞可能在女性中发挥作用.
虽然BDNF对疼痛至关重要,但BDNF及其受体TrkB目前都不是可行的治疗点.

关键词:

亚洛迪尼亚 (allodynia) 是一种全气体的现象.中央敏感化中心背部角背部角微质细胞中的微质细胞神经病变是一种神经病变.在性爱中,性爱是性爱.

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