对于中风后认知障碍的血液生物标志物:系统性审查和元分析
Yuxia Ma1, Yanru Chen2, Tingting Yang3
1The First School of Clinical Medicine, School of Nursing, Lanzhou University, Lanzhou, Gansu Province, 730000, PR China.
概括
这次元分析确定了中风后认知障碍 (PSCI) 的关键血液生物标志物. 高水平的homocysteine,CRP,尿酸,IL-6,cystatin C,肌素和TNF-α表明PSCI风险增加.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 脑卒中后认知障碍 (PSCI) 显著影响中风幸存者的生活质量和预后.
- 确定可靠的PSCI生物标志物对于早期检测和管理至关重要.
- 关于PSCI血液生物标志物的现有研究显示出各种结果,需要一个全面的摘要.
研究的目的:
- 进行一项元分析,总结与PSCI相关的潜在血液生物标志物.
- 确定用于预测和诊断中风后认知障碍的关键指标.
主要方法:
- 进行了主要科学数据库 (PubMed,科学网,Embase,科克兰图书馆) 的系统搜索.
- 包括到2022年4月15日发表的研究,探索血液生物标志物和PSCI.
- 从63个选定的研究中对20个潜在的血液生物标志物候选者进行了元分析.
主要成果:
- 在63项研究中确定了与PSCI相关的95种血液生物标志物.
- 在患有PSCI的患者中,观察到显著增加的同类半氨酸 (Hcy),C反应蛋白 (CRP),尿酸 (UA),互白素-6 (IL-6),cystatin C (Cys-C),肌素和瘤坏死因子-α (TNF-α) 的水平.
- 对于所有已识别的生物标志物,发现了统计学意义 (P < 0.05),具有显著的影响大小.
结论:
- Hcy,CRP,UA,IL-6,Cys-C,肌素和TNF-α是评估PSCI风险的推血液生物标志物.
- 这些生物标志物,结合神经成像和神经心理评估,可以帮助早期发现PSCI和预防策略.
- 需要在未来的研究中进一步验证其他潜在的生物标志物.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
91
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
153