脑小血管疾病的血基生物标志物
Liu-Yun Wu1, Yuek Ling Chai1, Irwin K Cheah2
1Memory Aging and Cognition Centre, National University Health System, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ageing research reviews
|February 28, 2024
概括
年龄相关的大脑小血管疾病 (CSVD) 是一种影响老龄化人口的异质性疾病. 了解其潜在机制对于开发可访问的基于血液的生物标志物对于早期检测和风险分层至关重要.
科学领域:
- 神经学 神经学
- 血管生物学 血管生物学
- 生物标志物发现发现
背景情况:
- 年龄相关的大脑小血管疾病 (CSVD) 是一种异质的疾病,导致慢性脑血管功能障碍,中风和血管认知障碍.
- 神经成像检测到CSVD,但资源密集;因此,寻求基于血液的生物标志物进行可访问的查.
- 了解CSVD的发病因子对于确定临床上有用的生物标志物至关重要.
研究的目的:
- 为了提供CSVD病原体的概述.
- 审查涉及CSVD的关键生物分子的临床研究.
- 概述CSVD生物标志物发现和验证的未来方向.
主要方法:
- 审查CSVD发病过程中的病理生理过程,包括内皮损伤,神经炎症,氧化应激和心血管功能障碍.
- 对涉及CSVD的生物分子的临床研究进行了全面的审查.
- 对CSVD生物标志物研究当前趋势和未来前景的分析.
主要成果:
- CSVD的发病包括内皮功能障碍,神经炎症,氧化应激,周血管损伤和心血管问题.
- 许多生物分子参与了这些过程,目前正在研究它们的诊断和预后价值.
- 神经影像,虽然先进,仍然是广泛的CSVD查的一个障碍.
结论:
- 开发可访问的CSVD血基生物标志物是早期检测和风险分层的优先事项.
- 为了临床验证,需要对CSVD病原和相关生物分子进行进一步的研究.
- 未来的努力应集中在将生物标志物研究转化为实际的临床工具,用于管理与年龄相关的脑血管疾病.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
153
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
153
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
91
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
91