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基于脂质的SEDDS的开发,使用长链甘油三的消化产品来提高药物溶解度:配方和分散测试

Heta H Desai1, Abu T M Serajuddin2

  • 1Department of Pharmaceutical Sciences, St. John's University, 8000 Utopia Parkway, Queens, NY 11439, USA; Present Address: Pace Life Sciences, 19 Presidential Way, Woburn, MA 01801, USA.

International journal of pharmaceutics
|February 28, 2024
PubMed
概括

这项研究开发了一种使用脂质消化产品的自我乳化药物递送系统 (SEDDS),以提高薄弱基性药物的溶解性,如肉和利托纳维尔. 该配方改善了药物负载和在胃肠道液体中的分散性.

关键词:
胆盐:胆盐是一种胆盐.在Cinnarizine中使用.分散试验 散布试验脂质消化产品的消化产品长链脂肪酸是一种长链脂肪酸.这是一种微乳液微乳液.里托纳维尔 (Ritonavir) 是一种药物.这些是SEDDS.自体乳化药物输送系统自体乳化药物输送系统可溶性 溶解度 溶解度 溶解度

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