同结晶改善了利古斯特拉的可平板性,尽管可塑性减少了
Gerrit Vreeman1, Danyingzi Guan2, Yuncheng Cai3
1Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States.
International journal of pharmaceutics
|February 28, 2024
概括
同结晶改变了晶体的机械性质,以更好地进行平板化. 利古斯特拉-酸共同晶体令人惊地提高了可平板性,仅仅显示可塑性并不能预测性能.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 晶体工程公司 晶体工程公司
背景情况:
- 同结晶是提高药物的物理化学性能的关键策略.
- 利古斯特拉 (LIG) 由于过度压缩而表现不佳,尽管具有高可塑性.
- 了解晶体结构与特性关系对于制药开发至关重要.
研究的目的:
- 为了研究ligustrazine (LIG) 与马龙酸 (MA) 和酸 (SA) 的联合结晶.
- 评估共晶形成对LIG的机械性能和平板性能的影响.
- 探索晶体结构,机械性能和表化性之间的相互作用.
主要方法:
- 晶合成LIG-MA和LIG-SA. 这是一个非常好的方法.
- 在模具中进行Heckel分析,以评估可塑性和可平板性.
- 能源框架分析,以调查晶格子能量.
- 基因化合物和共晶体的机械性质评估.
主要成果:
- 两种LIG-MA和LIG-SA共晶体的可塑性都比LIG.
- 与LIG.MA相比,LIG-MA联合晶体的可平板性略有降低.
- 与可塑性预测相反,LIG-SA共晶体显示出更好的可平板化.
- 在LIG-SA中,较高的结合强度被确定为增强表格性的原因.
结论:
- 同结晶可以调节晶体的机械性质和平板电池的性能.
- 仅仅基于可塑性的可塑性预测可能是不可靠的.
- 考虑结合面积和强度的综合方法对于预测晶体形式表化性至关重要.
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