使用心肺健康评估来识别长期COVID中的病理生理学 - 最佳实践方法
Mark A Faghy1, Caroline Dalton2, Rae Duncan3
1Biomedical and Clinical Exercise Science Research Theme, University of Derby, Derby, UK; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA; Healthy Living for Pandemic Event Protection Network, Chicago, IL, USA.
Progress in cardiovascular diseases
|February 28, 2024
概括
心肺运动测试 (CPET) 可以评估长期COVID患者的心肺呼吸能力 (CRF). 谨慎的CPET协议设计至关重要,以避免由于后炼症状恶化 (PESE) 而导致症状恶化.
科学领域:
- 生理学 生理学 生理学
- 临床医学 临床医学
- 病理生理学 病理生理学
背景情况:
- 长期COVID影响全球数百万人,有超过200种症状,显著影响生活质量和功能状态.
- 后炼症状恶化 (PESE) 是长期COVID的标志,由身体,情绪,静态或认知刺激引发,阻碍日常活动.
- 心肺健康 (CRF) 是一个关键的生理测量,其评估对于了解长期COVID至关重要.
研究的目的:
- 探索心肺运动测试 (CPET) 在理解长期COVID病理生理学的作用.
- 为开发安全有效的长期COVID治疗和管理策略提供信息.
- 解决需要研究的需求,考虑长期COVID的复杂,多系统性质.
主要方法:
- 使用心肺运动测试 (CPET) 作为评估综合生理学的标准方法.
- 考虑到CPET期间患有慢性病的患者PESE的固有风险.
- 设计研究协议,以考虑长期COVID的复杂多系统病理生理学.
主要成果:
- CPET是评估CRF和理解长期COVID中的生理反应的宝贵工具.
- 以前的慢性疾病中CPET尝试被PESE复杂化,导致症状恶化.
- 如果CPET协议没有经过精心设计,就存在恶化长期COVID症状的重大风险.
结论:
- CPET对推进对长期COVID的机制性理解具有前景.
- 在长期COVID研究中实施CPET时,仔细考虑PESE至关重要.
- 未来的研究必须优先考虑参与者安全和对长期COVID的强有力的机械洞察力.
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