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Updated: Jul 2, 2025

A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
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面对改变等离子体蛋白结合的事实:当前的模型是否正确预测特殊人群中未结合部分的变化?

Jokha Al-Qassabi1, Shawn Pei Feng Tan2, Patcharapan Phonboon2

  • 1Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK; University of Technology and Applied Sciences, Oman.

Journal of pharmaceutical sciences
|February 28, 2024
PubMed
概括

基于生理学的药物动力学模型通常通过调整血蛋白度变化来预测药物未结合分量 (fu). 然而,这种方法无法准确地预测特殊人群之间的变化,因此需要考虑其他约束因素.

关键词:
专辑中的专辑蛋白.这是一种α1-酸性糖蛋白蛋白.机械建模机械建模基于生理学的药理动力学 (pbpk) 建模它与蛋白质结合.特殊种群的特殊种群.

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