婴儿的脑体积与metopic synostosis:少白质体积与加速增长的模式在早期的生活
L Gaillard1, M C Tjaberinga1, M H G Dremmen2
1Department of Plastic and Reconstructive Surgery and Hand Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Journal of anatomy
|February 28, 2024
概括
梅托皮性协与较小的白质体积和加快的白质生长有关,类似于自闭症. 其他大脑体积在患者和对照人群之间是可比的,这表明大脑内在的异常.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 甲基突突,甲基突突的过早融合,与神经发育障碍有关.
- 虽然内高血压的风险很低,但潜在的大脑病理生理学仍然不清楚.
研究的目的:
- 通过使用手术前核磁共振 (MRI) 检查非综合征性美托皮性静止病患者的全球和区域大脑体积.
- 识别可能导致相关神经发育障碍的潜在大脑异常.
主要方法:
- 使用HyperDenseNet处理MRI扫描来量化内体积 (TIV),大脑总体积 (TBV),灰质体积 (TGMV),白质体积 (TWMV) 和脑脊液体积 (TCBFV).
- 采用线性回归来比较45名美托皮性结合症患者和14名对照患者之间的大脑体积,并根据年龄和性别进行调整.
- 对叶片特异性灰质体积进行了二次分析.
主要成果:
- 在患者和对照组之间没有发现TIV,TBV,TGMV或TCBFV的显著差异.
- 总白质体积 (TWMV) 在metopic synostosis患者中明显较小.
- 在患者中观察到加速白质生长模式,反映了自闭症谱系障碍中观察到的模式.
结论:
- 梅托皮性协与减少TWMV和改变白质生长动态有关.
- 二次分析表明,带膜体和部灰质体积较大.
- 研究结果表明,与metopic synostosis相关的神经发育障碍的病理生理学中存在普遍的内在大脑异常.
关键词:
这就是为什么MRI是MRI.大脑体积大脑体积的大脑体积头骨突突症 (craniosynostosis) 是一种灰色物质是一种灰色物质.这是一种metopic synostosis.有三角头脑症的三角头脑症.白质是白色物质的组成部分.更多相关视频
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