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Kensuke Nakajima¹, Ahreum Han¹, Arisa Kayano¹

¹Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University.

Journal of nutritional science and vitaminology

|February 28, 2024

概括

来自13个品种的果皮和果肉可以增加细胞中的来自大脑的神经营养因子 (BDNF). 这一发现表明,对于中枢神经系统疾病,如抑郁症,阿尔茨海默氏症等,潜在的新型基于食物的治疗方法.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

大脑衍生神经营养因子 (BDNF) 对于神经元的生存和突触可塑性至关重要.
提升BDNF可以帮助预防和治疗中枢神经系统 (CNS) 疾病,如抑郁症,阿尔茨海默病 (AD) 和帕金森病 (PD).
外围BDNF可以穿越血脑屏障,使外围组织点与中枢神经系统疾病治疗相关.

研究的目的:

调查各种类品种对BDNF生产的影响.
为了确定特定的类品种具有BDNF-upregulating特性,用于潜在的治疗用途.

主要方法:

培养的人类腺癌细胞 (ACHN) 用21种果品种 (皮和肉质) 的提取物进行治疗.
细胞培养基中的BDNF水平被测量以评估生产.
对某些有效类品种的BDNF转录水平进行了分析.

主要成果:

使用21种类中13种类的皮和肉质治疗显著增加了ACHN细胞中的BDNF水平.
属于Aurantium和Acrumen组的类品种及其杂交品种表现出强大的BDNF上调效应.
一些Acrumen和混合类治疗也提高了BDNF转录水平,表明转录调节.

结论:

许多类果皮含有可以提高BDNF产量的化合物.
这些发现表明类衍生化合物在治疗中枢神经系统疾病 (如抑郁症,AD和PD) 中具有新的治疗潜力.
各种类种类可以作为有益的食物来提高BDNF水平.

关键词:

ACHN 细胞 ACHN 细胞阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.这就是为什么BDNF是BDNF.帕金森病是帕金森氏症的一种疾病.血脑屏障是什么意思中枢神经系统疾病中枢神经系统疾病果果皮和果粉的果皮和果粉.抑郁抑郁症抑郁症抑郁症抑郁症功能性食品是一种功能性食品.

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