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短期缺乏的饮食通过Ca吸收相关的基因表达维持血清度
Takako Suzuki1,2, Kazuharu Suzuki3, Jun Takahashi2
1Department of Human Nutrition, Faculty of Human Nutrition, Tokyo Kasei Gakuin University.
Journal of nutritional science and vitaminology
|February 28, 2024
概括
在老鼠中短期的缺乏通过改变十二指肠基因表达来维持血清. 它还增加了中的Cyp24a1表达,以应对更高的维生素D水平.
科学领域:
- 营养生物化学 营养生物化学
- 矿物质的新陈代谢.
- 分子内分泌学分子内分泌学
背景情况:
- 是一种必不可少的矿物质,对许多生理过程至关重要.
- 平衡受到严格调节,并受到包括在内的各种营养素的影响.
- 维生素D在的吸收和新陈代谢中起着关键作用.
研究的目的:
- 研究短期饮食缺乏对大鼠和代谢的影响.
- 检查载体和相关基因对缺乏症的反应中的分子反应.
主要方法:
- 四周大的雄性Wistar大鼠被食缺乏 (1ppm) 或控制 (30ppm) 饮食一周.
- 使用定量实时PCR测量肝脏,脏和十二指肠中特定基因的mRNA表达.
- 分析了血清中的和1,25-二基胆 (1,25(OH) 2D3) 的水平.
主要成果:
- 饮食中缺乏迅速改变了多种组织中关键载体 (Zip和ZnT家族) 的mRNA表达.
- 血清水平保持不变,但血清1,25(OH) 2D3在缺乏的老鼠中增加.
- 缺可提高十二指肠中与吸收相关的基因 (TRPV6,S100g,Atp2b1) 的表达.
- 在缺乏的老鼠中,维生素D受体 (VDR) 和Cyp24a1的表达升高.
结论:
- 短期的缺乏症可以通过调节参与吸收的十二指肠基因表达来维持血清水平.
- 缺乏症中24a1表达的增加似乎是对血清1,25(OH) 2D3水平升高的反应.
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