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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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工程化树皮细胞衍生因子-1αα的结构和功能.

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  • 1Department of Biomaterials, Graduate School of Biomedical and Health Sciences, Hiroshima University.

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合成的化学蛋白质结合了带状细胞衍生因子-1α (SDF) 和原结合域 (CBD),用于骨组织工程. 连接这些域会影响它们的功能,但它们的顺序对整体3D结构的影响很小.

关键词:
基默蛋白质是一种基默蛋白质.脚手架是一个脚手架.结构预测结构预测组织工程是组织工程.

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科学领域:

  • 生物材料科学 生物材料科学
  • 组织工程是组织工程.
  • 蛋白质工程是指蛋白质工程.

背景情况:

  • 基于原的支架对于骨组织工程至关重要.
  • 流体细胞衍生因子-1α (SDF) 和·维勒布兰德因子A3原结合域 (CBD) 是关键的功能成分.
  • 了解域链接效应对于脚手架设计至关重要.

研究的目的:

  • 为了合成和表征SDF和CBD的化学蛋白质,用于骨架.
  • 研究域链接和序列对蛋白质结构和功能的影响.
  • 评估这些嵌合蛋白在组织工程应用中的潜力.

主要方法:

  • 合成含有SDF和CBD的仿制蛋白质.
  • 使用循环二重化谱法进行结构分析.
  • 功能性检测包括细胞迁移 (SDF) 和原结合 (CBD).
  • 计算结构预测.

主要成果:

  • 化学蛋白质合成是成功的.
  • 连接SDF和CBD领域影响了它们的个别功能.
  • 域链接的顺序对SDF和CBD的3D结构的影响最小.
  • 计算预测与实验发现保持一致.

结论:

  • 化学蛋白质可以被设计为骨组织工程支架.
  • 域链接会影响蛋白质的功能,因此需要精心设计.
  • SDF和CBD域的顺序对它们的结构完整性有有限的影响.
  • 这些发现为开发先进生物材料提供了洞察力.