埃梅达斯抑制由母细胞介导的Th1和Th2细胞分化
Katsuhiko Matsui1, Akari Kuroki1, Aya Morishima1
1Department of Clinical Immunology, Meiji Pharmaceutical University.
Biological & pharmaceutical bulletin
|February 28, 2024
概括
埃梅达斯是一种抗组胺药物,抑制由巨细胞介导的T辅助细胞分化. 这种药物通过抑制巨细胞上的CD86表达来减少炎症,为亚托皮炎提供潜在的益处.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 埃梅达斯是一种第二代抗胰岛素,此前已被证明可以通过兰格汉斯细胞 (LCs) 抑制T助手1 (Th1) /Th2细胞分化.
- 乳腺细胞被认为是诱导Th1/Th2细胞分化的抗原呈现细胞 (APC),但埃梅达斯对这种功能的影响尚不清楚.
研究的目的:
- 为了研究埃梅达斯对瘤细胞介导的Th1/Th2细胞分化的影响.
- 为了确定埃梅达斯是否会影响巨细胞介导的免疫反应.
主要方法:
- 培养了小鼠巨细胞,并用埃梅达斯治疗.
- mast细胞与天真的CD4+T细胞和卵蛋白一起共同培养.
- 分析了Th1/Th2细胞因子的产生和CD86的表达,使用酶相关的免疫吸收试验和流动细胞计.
主要成果:
- 埃梅达斯治疗显著抑制了激活的T细胞产生的干扰素- (IFN-γ) 和介质素-4 (IL-4) 的产生.
- 这种抑制与减少瘤细胞的CD86表达相关.
- 埃梅达斯通过降低瘤细胞上CD86表达的调节来抑制Th1和Th2细胞分化.
结论:
- 埃梅达斯抑制Th1/Th2细胞分化,由作为APC的瘤细胞介导.
- 该药物通过降低CD86表达的调节来降低杆细胞介导的皮肤炎症.
- 局部使用的埃梅达斯可以通过向LC和乳腺细胞介导通路来减少亚托皮炎的炎症.
更多相关视频
08:25An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation
Published on: April 27, 2021
2.4K
11:31Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
Published on: July 4, 2018
12.3K
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
294
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
294
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
