孕产妇喘和后代结果的临床前模型:一个范围审查
Joshua L Robinson1,2,3, Kathryn L Gatford1,4, Danielle N Bailey1
1Robinson Research Institute, University of Adelaide, Adelaide, Australia.
概括
这次审查检查了母亲喘的临床前模型,发现大多数研究使用了动物,并报告了实验设计. 然而,数据排除,盲目和不良事件的报告不一致,阻碍了临床翻译.
科学领域:
- 生殖生物学 生殖生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 怀孕期间的喘增加了不良的围产期结果,其机制基本上是未知的.
- 了解这些机制需要临床前模型来隔离遗传和并发症影响.
- 动物模型允许对潜在干预措施进行安全测试.
研究的目的:
- 对临床前母亲喘模型进行范围审查.
- 探索它们的方法,表型,特征,结果和质量.
- 确定局限性,并建议改善临床翻译.
主要方法:
- 在 MEDLINE,Embase 和 Web of Science 数据库中进行系统搜索.
- 由两个审查员进行独立选和数据提取.
- 使用ARRIVE 2.0指南进行质量评估.
主要成果:
- 在3618项已确定的研究中,有39项符合条件的研究;大多数用于过敏喘的动物模型.
- 常见的结果包括气道过敏反应,炎症和免疫反应.
- 报告在实验设计方面表现强,但在数据排除,盲目和不良事件方面表现弱.
结论:
- 在临床前母亲喘模型中,对关键的方法细节和结果指标的不一致报告可能会阻碍临床翻译.
- 物种差异和使用非人类相关的过敏原是潜在的障碍.
- 未来的研究应该采用最低核心成果,以提高一致性和转化潜力.
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