[老年人的慢性病]
Oana Ailioaie1, Marie Essig2, Hélène Levassort3
1Service de néphrologie, Université Paris-Saclay, Site Ambroise-Paré, AP-HP, Boulogne-Billancourt, France.
Soins. Gerontologie
|February 28, 2024
概括
慢性病 (CKD) 影响全球健康,特别是在老年人中. 早期识别风险因素和改善管理对于减少并发症和心血管风险至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 老年病的医生 老年病的医生
背景情况:
- 慢性病 (CKD) 是一个重要的全球健康问题,影响了全球近10%的人口.
- 患病率随着年龄的增长而大幅增加,在70岁以上的人群中超过30%.
- 虽然在一些地区稳定,但在老年人群 (85岁以上) 中,CKD发病率正在迅速增加.
研究的目的:
- 突出慢性病的广泛影响和日益增长的发病率,特别是在老年人群中.
- 为了强调与晚期CKD相关的严重并发症.
- 强调需要改进风险因素理解和管理策略的必要性.
主要方法:
- 本摘要总结了关于慢性病的流行病学数据和临床观察结果.
- 它审查了与疾病晚期相关的已知并发症和危险因素.
- 该文本倡导加强治疗教育和为支持性治疗做准备.
主要成果:
- 慢性病 (CKD) 影响着全球人口的很大一部分,85岁以上的人群显著增加.
- 晚期CKD会导致严重的并发症,包括电解质失衡,贫血和心血管风险增加.
- 目前的理解表明,改善风险因素管理和患者教育是关键.
结论:
- 慢性病 (CKD) 的有效管理需要采用综合方法,重点关注风险因素和患者的准备.
- 脏保护策略和治疗教育对于缓解CKD并发症至关重要.
- 进一步的研究和改善的临床实践是必要的,以应对不断增加的CKD负担,特别是在老年人.
相关概念视频
Nephrons
2.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.4K
Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
Dialysis
309
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
309
Renal Failure: Dose Adjustments
88
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
88
Renal Corpuscle
2.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.1K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
61
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
61


