相关实验视频

Updated: Jul 2, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

使用JADER数据库对抗CD20抗体的Bendamustine进行细胞巨病毒发生率和发病时间分析

Kaori Ito^1,2,3, Takenao Koseki², Misaki Morisaku²

¹Faculty of Pharmacy, Meijo University, Nagoya, Japan; itoka@meijo-u.ac.jp.

In vivo (Athens, Greece)

|February 28, 2024

概括

与Rituximab或Obinutuzumab的Bendamustine组合疗法可能会增加淋巴瘤患者的细胞巨型病毒 (CMV) 感染持续时间. 建议在治疗后对细胞介导免疫的进一步研究.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药物监督药物监督药物监督

背景情况:

患有恶性淋巴瘤的患者免疫功能减弱,增加了化疗诱导的免疫抑制和细胞巨乳病毒 (CMV) 感染的风险.
同时使用班达穆斯丁和瑞图西马布或奥比努图祖马布的治疗加剧了免疫抑制,可能会影响CMV的发病.

研究的目的:

评估bendamustine单疗法和与rituximab或obinutuzumab联合治疗之间的CMV发病的差异.
使用日本药物不良事件报告数据库 (JADER) 进行分析.

主要方法:

分析了2004年4月至2022年9月的JADER数据.
使用MedDRA首选术语定义的CMV感染.
计算的报告几率比率 (ROR) 对于CMV信号的bendamustine单疗法,修仙药,奥比努图祖马布,bendamustine+rituximab (BR),和bendamustine+obinutuzumab (GB).

主要成果:

在单疗法和组合疗法中证实了CMV信号.
平均CMV感染持续时间为bendamustine单疗41.0天,BR为63.5天,GB为61.0天.
一些CMV感染病例超过200天.

结论:

在JADER分析中,发现了与rituximab,obinutuzumab和bendamustine相关的显著CMV信号.
建议对可能的CMV再激活在bendamustine给药7-9个月后保持谨慎.
需要对细胞介导免疫抑制进行进一步的研究.

关键词:

我们必须曲.日本药物不良事件报告数据库.对抗CD20单克隆抗体的抗体.细胞巨型病毒感染.

更多相关视频

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation

Published on: December 26, 2017

相关概念视频

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...