在小鼠中缺血性中风后,Bifico可改善神经缺陷:转录基因组剖析
Yanfei Han1, Huizhen Xu1, Shaoxin Tao1
1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China.
In vivo (Athens, Greece)
|February 28, 2024
概括
益生菌Bifico预治疗减少了中风引起的脑损伤,并改善了小鼠的神经功能. 这表明Bifico可能调节大脑免疫力和炎症,为中风恢复提供了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 在中风患者中,肠道微生物群的组成发生了变化,有害细菌增加,有益细菌减少.
- 这种失生症可以增加肠道透性,感染风险和炎症因素,可能会影响中风的结果.
- 益生菌可以改善肠道环境,并影响中风预后.
研究的目的:
- 为了研究益生菌Bifico对小鼠在焦点脑缺血后神经功能的影响.
- 在中风模型中探索Bifico作用的潜在机制.
主要方法:
- 在小鼠中建立了焦点脑缺血模型,分组接受载体,前Bifico或Bifico治疗.
- 评估了心脏病发作量和神经行为结果.
- 整个基因表达概况 (RNA-seq),基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 分析是在不同时间点收集的样本上进行的.
主要成果:
- 与对照组相比,Bifico的预治疗显著降低了心脏病发作量,并改善了神经学评分.
- 基因表达分析揭示了不同组之间差异表达基因 (DEG) 和丰富通路 (GO,KEGG) 的显著差异.
- 特定的免疫和炎症相关基因显示出改变的表达模式,其中一些在中风恢复期间升调.
结论:
- 在小鼠中,使用Bifico进行28天的口服预治疗有效地减少了脑梗塞,并促进了神经功能恢复.
- 这些好处很可能是通过调节大脑免疫和炎症来调节的.
- 比菲科显示出作为改善中风结果的治疗剂的潜力.
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