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通过使用共聚焦激光内微镜系统对胃癌组织进行实时组织学评估

Hyunsik Bae¹, Haeyon Cho², Yeonju Jo³

¹Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

In vivo (Athens, Greece)

|February 28, 2024

概括

一个新的共聚焦激光内微镜系统 (CLES) 提供实时胃癌组织成像. 在CLES图像审查后,病理学家的准确性显著提高,显示了其快速组织学评估的潜力.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
医疗成像医学成像

背景情况:

对新鲜组织的即时组织学评估对于癌症治疗至关重要.
传统的冷截面技术有其局限性.
同焦激光内分显微镜 (CLES) 提供实时组织成像,无需幻灯片准备.

研究的目的:

评估一种新的CLES用于胃癌组织的组织学评估的适用性.
评估CLES在识别胃癌方面的诊断性能.
为了比较CLES的性能与传统的血素和素 (H&E) 染色.

主要方法:

一个CLES系统被开发并用于成像14个新鲜的胃癌和14个正常的胃组织.
光素被用于染色.
五位病理学家解释了CLES图像的组织学位置和癌症存在,与H&E幻灯片对性能进行了评估.

主要成果:

CLES图像准确地反映了胃组织组织学.
最初的CLES解释显示位置准确率为65.7%,癌症检测准确率为74.7%.
在H&E后的审查中,精度显著提高到92.8%的位置和90.9%的癌症检测,增强了灵敏度和特异性.

结论:

CLES系统可以实时获取高质量的组织学图像.
操作员培训提高了胃癌的CLES诊断准确度.
对于改善癌症诊断,CLES显示出作为实时组织成像模式的潜力.

关键词:

胃癌是什么?胃癌是什么?同焦点的激光内微镜.组织学组织学组织学实时成像成像是可以实现的.

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