血清CCDC25水平作为代谢综合征的潜在标志物
Anousone Phimphila1, Tin May Aung1, Molin Wongwattanakul1,2
1Centre of Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
In vivo (Athens, Greece)
|February 28, 2024
概括
含有25 (CCDC25) 水平的血清卷曲卷曲域在患有代谢综合征 (MetS) 的个体中显著升高. 更高的CCDC25表明更多的MetS标准,表明其作为代谢性疾病进展的生物标志物的潜力.
科学领域:
- 生物化学 生化学
- 代谢学 代谢学 代谢学
- 临床生物标志物 临床生物标志物
背景情况:
- 代谢综合征 (MetS) 是严重健康状况的主要危险因素.
- 识别代谢条件的生物标志物对于改善健康结果至关重要.
- 之前的生物信息学分析表明,含有25 (CCDC25) 的卷状卷域与代谢途径有关.
研究的目的:
- 为了研究血清中CCDC25水平与MetS状态之间的关联.
- 探索CCDC25作为代谢综合征及其组成部分的潜在生物标志物.
主要方法:
- 根据修改的NCEP-ATP III标准,参与者被分为MetS,前MetS和健康对照 (HC) 组.
- 血清中CCDC25水平使用点点检测量量化.
- 分析了CCDC25水平和MetS标准 (甘油三,缩血压,高血糖水平-C) 之间的相关性.
主要成果:
- 在MetS组中,血清CCDC25水平明显高于MetS前和HC组 (p<0.001).
- 在血清CCDC25水平和MetS异常标准数量之间观察到正相关性.
- CCDC25水平与甘油三 (TG),静态血压 (SBP) 和高密度脂蛋白胆固醇 (HDL-C) 有着强烈的相关性.
结论:
- CCDC25水平与代谢综合征及其各个组成部分有显著的关联.
- 与TG,SBP和HDL-C的强烈相关性表明CCDC25在代谢失调中的作用.
- 血清CCDC25的升高可能作为MetS相关疾病的发展和进展的指标.
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