酒精摄入量的变化和血清尿酸的变化:对年度医学检查数据库的纵向分析
Sho Fukui1,2,3, Masato Okada2, Tomohiro Shinozaki4
1Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA sfukui@bwh.harvard.edu dsolomon@bwh.harvard.edu.
Annals of the rheumatic diseases
|February 28, 2024
概括
减少酒精摄入量显示血清尿酸盐 (SU) 水平略微但显著下降. 完全停止饮酒的效果很小,特别是在高尿素血症患者中.
科学领域:
- 代谢健康 代谢健康
- 痛风和高尿血研究研究
- 纵向健康研究 纵向健康研究
背景情况:
- 在酒精消费和血清尿酸盐 (SU) 之间建立了横截面联系.
- 酒精摄入量变化对SU水平的长度影响尚不清楚.
- 需要评估SU的酒精摄入量修改的临床相关性.
研究的目的:
- 为了研究酒精摄入量和血清尿酸盐 (SU) 水平变化之间的纵向关联.
- 为了确定酒精消费的改变是否对SU有临床显著的影响.
- 分析日本人口中酒精摄入量变化的影响.
主要方法:
- 年度医学检查数据 (2012-2022) 的回顾性分析.
- 包括来自日本预防医学中心的63,486名参与者.
- 混合效应线性回归模型用于评估SU变化与酒精摄入量变化相关的变化,调整共变量.
主要成果:
- 每天饮酒量减少1杯饮料与SU的小幅降低有关 (-0.019 mg/dL).
- 酒消费显示,与每种饮料的SU减少的最大关联.
- 完全戒酒导致SU的适度下降 (-0.056 mg/dL),在高尿素血症患者中效果更为明显 (-0.110 mg/dL).
结论:
- 在日本一般人口中,酒精摄入量的变化与血清尿酸盐的波动有很小的关联.
- 完全停止饮酒可以适度地改善SU水平,特别是在那些患有高尿血的人群中.
- 调查结果表明,虽然减少饮酒对SU的影响很大,但在人口层面上,这种影响通常很小.
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