怀孕期间维生素D水平对早产的影响:系统审查协议
Olívia Barbosa1,2,3, Margarida Sim-Sim4, Marta Pereira Silvestre5
1University of Évora, Évora, Portugal engenheiro.olivia@gmail.com.
BMJ open
|February 28, 2024
概括
孕妇在怀孕期间缺乏维生素D可能会增加早产风险. 本系统性审查审查了不确的证据和潜在的机制,强调了维生素D补充对产前护理和公共卫生政策的影响.
科学领域:
- 产科和妇科 产科和妇科
- 公共卫生 公共卫生
- 营养科学 营养科学
背景情况:
- 过早生育是一个重大的全球健康问题.
- 怀孕期间母亲的维生素D缺乏症 (维生素D缺乏症) 越来越多地与早产风险更高有关.
- 现有的证据是不确定的,缺乏关于关联和潜在机制的共识.
研究的目的:
- 系统地审查当前关于母亲维生素D状况与早产之间的关联的文献.
- 探索潜在的生物学机制,将低维生素D水平与不良妊娠结果联系起来.
- 为临床实践和公共卫生战略提供有关怀孕期间维生素D补充剂的信息.
主要方法:
- 从2018年1月到2022年11月,在多个电子数据库 (例如,MEDLINE,PubMed,Scopus) 进行了全面的系统文献搜索.
- 包括量化初级研究 (临床试验,队列,横截面,病例控制研究),使用与维生素D和早产有关的术语.
- 研究质量由两位审稿人独立评估,使用既有工具 (科克莱恩偏差风险,纽卡斯尔太华尺度).
主要成果:
- 这个部分是在审查完成后填写的.
- 审查将综合包括的研究的发现,以评估关联的强度和一致性.
- 分析将考虑潜在的混因素和效果修饰剂.
结论:
- 这次审查将提供有关母亲维生素D和早产的最新证据综合.
- 这些发现可以澄清维生素D在怀孕健康中的作用,并为补充剂的建议提供信息.
- 结果对通过有针对性的公共卫生干预来降低早产率有潜在的影响.
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