在骨血管栓塞后,何时可以安全地开始进行血栓预防?
Brianna L Collie1, Nicole B Lyons1, Christopher F O'Neil1
1Dewitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, and Ryder Trauma Center, Miami, FL.
Surgery
|February 28, 2024
概括
在脏血管栓塞发生后24至72小时开始血栓预防,可以平衡出血和静脉血栓栓塞的风险. 对于患者的安全来说,在形脏创伤中进行血栓预防的最佳时间是至关重要的.
科学领域:
- 创伤外科 手术 创伤外科
- 血管外科 血管外科
- 关键护理医学 关键护理医学
背景情况:
- 由于出血风险,在形脏创伤后的血栓预防是复杂的.
- 在骨血管栓塞后进行血栓预防的具体风险尚不清楚.
- 早些时候的血栓预防可能会增加出血,而不会减少静脉血栓塞栓症 (VTE).
研究的目的:
- 评估开始血栓预防的时间与骨血管栓塞后出血并发症之间的关联.
- 为了确定早期启动血栓预防治疗是否能减轻骨创伤患者的静脉动脉突发症事件.
- 确定启动血栓预防的最佳窗口,以平衡出血和VTE风险.
主要方法:
- 美国外科医生学院创伤质量改善计划 (2017-2019) 的分析.
- 包括在24小时内接受脏血管栓塞的重创伤患者.
- 排除短期住院,重伤或血管栓塞前手术的患者;使用千平方和逻辑回归进行比较.
主要成果:
- 在1,102名患者中,73%接受了血栓预防治疗,84%患有高度脏损伤.
- 在24小时内启动血栓预防治疗后,脏手术后血管栓塞增加 (5.7%对1.7%).
- 延迟开始 (72小时后) 与较高的肺栓塞率 (2.3%与0.2%) 相关联,多变量分析将时间与出血和VTE并发症联系在一起.
结论:
- 在24到72小时之间启动血栓预防提供了最大的平衡,最大限度地减少出血和VTE风险.
- 建议使用48小时的间隔作为协议化血栓预防药物管理的理想时间.
- 这项国家研究为优化脏血管栓塞后的血栓预防时间提供了关键的见解.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
696
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
696
Radiological Investigation III: Pulmonary Angiogram and PET Scan
92
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
92
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
523
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
523


