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结节的位置是AUS/FLUS甲状腺结节癌症的预测风险因素吗? 一个回顾性队列研究

Saad M Alqahtani¹, Bassam A Altalhi², Yousef S Alalawi³

¹Department of Surgery, College of Medicine, Majmaah University, Riyadh-Qassim road, Al-Majmaah, 11952, Saudi Arabia.

Asian journal of surgery

|February 28, 2024

概括

结节的位置是甲状腺结节中恶性瘤的有希望的预测因子,这些结节被归类为未确定的意义 (AUS/FLUS) 的非典型或卵泡病变. 缺口结节显示出患恶性瘤的最高风险,需要仔细评估.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
病理学病理学病理学

背景情况:

不确定的意义上的型/毛囊病变 (AUS/FLUS) 代表了一种异质的甲状腺结节类别,其细胞学诊断不确定,管理策略有争议.
在AUS/FLUS结节中恶性瘤的风险仍然是一个临床挑战,需要改进风险分层工具.

研究的目的:

调查甲状腺结节位置与AUS/FLUS类别内的恶性瘤风险之间的关联.
确定结节位置是否可以作为AUS/FLUS甲状腺结节癌症的预测因素.

主要方法:

对102名被诊断患有AUS/FLUS甲状腺结节的患者进行了回顾性分析.
纳入标准:良性或分化良好的甲状腺癌的最终组织病理学和可用的结节位置数据.
统计评估和对社会人口统计,组织病理学和超声波数据的相关性,包括结节位置.

主要成果:

该研究发现AUS/FLUS队列中的恶性瘤率为47.1%.
位于上极,中极或下极的结节与癌症风险增加显著相关 (ORs从1.9到2.6).
缺口结节表现出最高的恶性瘤率 (66.7%),男性性别和外围光环的存在也与更高的恶性瘤风险有关.

结论:

甲状腺结节的位置,特别是特定极点或峡谷的参与,是AUS/FLUS结节中恶性瘤的重要预测因素.
缺口位置与最高的恶性瘤风险有关,这强调了需要仔细评估的必要性.
建议进行进一步的大规模前性研究,以验证这些发现,并完善对AUS/FLUS结节的风险评估.

关键词:

细胞学细胞学恶性瘤是一种恶性瘤.甲状腺癌是什么?甲状腺癌是什么?甲状腺结节甲状腺结节

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