脏生理学和疾病中的NRF2
Corry D Bondi1, Hannah L Hartman1, Roderick J Tan1
1Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Physiological reports
|February 28, 2024
概括
转录因子NRF2 (核因子红色素2相关因子2) 保护脏免受损伤. 然而,其在蛋白尿性脏疾病中的作用是复杂的,需要进一步研究.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 分子生物学分子生物学
- 细胞应激反应的应激反应
背景情况:
- 核因素红色素2相关因子2 (NRF2) 调节细胞保护基因对抗氧化应激和炎症.
- NRF2存在于脏中,并影响盐/水平衡.
- 动物模型表明NRF2可以防止管间隙损伤和病进展.
研究的目的:
- 审查NRF2在生物学中的双重作用,包括保护性和潜在的有害影响.
- 为了澄清围绕蛋白尿性脏疾病中NRF2向的争议.
- 总结有关病中调节NRF2活动的治疗潜力和风险的当前数据.
主要方法:
- 在脏生理学和病理学中对NRF2的现有研究的文献综述.
- 来自动物模型和涉及NRF2调节器的人类临床试验的数据分析.
- 关于NRF2对各种病的影响的综合证据,包括糖尿病病和阿尔波特综合征.
主要成果:
- NRF2激活在某些脏损伤中显示出保护作用,减少纤维化和缩.
- NRF2诱导剂巴多克索隆甲基 (CDDO-Me) 改善了人类的球过率,但没有减缓糖尿病病或阿尔波特综合征的疾病进展.
- 在人体研究中,巴多克索隆甲基与增加蛋白尿,水分保留和高血压等不良影响有关,在动物模型中得到了相互矛盾的结果.
结论:
- NRF2在蛋白尿球性疾病中的作用仍然是有争议和复杂的.
- 向NRF2具有对脏保护的潜在益处和重大风险,需要仔细考虑.
- 进一步的研究是必不可少的,以充分阐明NRF2在脏健康和疾病的多方面的影响.
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