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Updated: Jul 2, 2025

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一种抑制自身转录的抗CRISPR,同时阻断Cas9目标DNA结合的抗CRISPR

Xieshuting Deng1,2, Wei Sun1, Xueyan Li1,2

  • 1Key Laboratory of RNA Science and Engineering, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Nature communications
|February 28, 2024
PubMed
概括

AcrIIA15是一种抗CRISPR蛋白,通过模仿DNA来抑制金黄色葡萄球菌Cas9 (SaCas9). 它的结构揭示了阻断SaCas9和通过DNA结合自我调节转录的双重功能.

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