结核病和非结核性菌根性肺病的治疗发展
Véronique Dartois1,2, Thomas Dick3,4,5
1Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA. veronique.dartois@hmh-cdi.org.
Nature reviews. Drug discovery
|February 28, 2024
概括
结核病 (TB) 的药物发现有了显著的进展,但非结核菌菌 (NTM) 肺部疾病缺乏新的治疗方法. 将结核病研究策略应用于NTM可以加速治疗方案的开发.
科学领域:
- * 传染病研究研究.
- * 药物的发现和开发.
- * 菌根细菌病原体的产生
背景情况:
- * 结核病 (TB) 药物发现在过去二十年中取得了重大进展,这是由于公私合作伙伴关系和增加的资金.
- *非结核菌 (NTM) 肺部疾病已成为一个重大的健康问题,但其药物开发管道仍然严重欠发达.
- *结核病和NTM肺部疾病之间存在显著的差异和相似之处,影响治疗策略.
研究的目的:
- * 为了比较对结核病和NTM肺部疾病的生物学和药理学的理解.
- * 评估两种疾病的临床前和临床发展进展.
- * 确定结核病和NTM研究之间的知识差距和交叉受精的机会.
主要方法:
- *结核病和NTM疾病生物学和药理学的比较分析.
- *对结核病和NTM目前的临床前和临床开发管道的审查.
- * 文献综合,以确定相似之处,差异和知识差距.
主要成果:
- *结核病药物发现受益于对疾病生物学和先进的临床试验设计的更好理解.
- *NTM药物开发管道稀疏,与结核病的进展形成鲜明对比.
- *确定了结核病和NTM研究之间的关键知识差距和共享学习领域.
结论:
- *成功的结核病研究范式和网络,从基础科学到临床试验,应该适应NTM疾病.
- *利用现有的结核病研究基础设施和知识可以加速开发NTM肺部疾病的治疗方案.
- *跨学科的合作对于应对迫切需要新的NTM疗法至关重要.
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