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罗尔同源NHR-23对于C. elegans的发育时钟和昼夜时钟都至关重要

Shingo Hiroki¹, Hikari Yoshitane^2,3

¹Tokyo Metropolitan Institute of Medical Sciences, Tokyo, Japan. s.hiroki.phd.work2022@gmail.com.

Communications biology

|February 28, 2024

概括

基因nhr-23对成年C. elegans的昼夜节律至关重要,挑战了祖先昼夜钟基因单一周期的想法.

科学领域:

时间生物学时间生物学
分子生物学分子生物学
发展生物学发展生物学

背景情况:

动物拥有控制昼夜节律的内部生物钟.
在哺乳动物中,像周期这样的时钟基因编排了24小时的周期.
C. elegans表现出一个8小时的"发育时钟",用于变,与典型的昼夜节律不同.

研究的目的:

为了确定负责成人C. elegans的昼夜节律的基因.
调查时钟基因同类在C. elegans生物节奏中的作用.
了解生物种间昼夜时钟的演变.

主要方法:

在C. elegans中研究基因功能.
专注于nhr-23的作用,它是哺乳动物Ror基因的同类基因.
分析了成年C. elegans的转录节奏.

主要成果:

发现nhr-23对于成年C. elegans的昼夜转录节律至关重要.
证实了nhr-23在8小时变时钟中的已知作用.
表明nhr-23会影响成年C. elegans的昼夜节律.

结论:

nhr-23在C. elegans的发育 (变) 和成年生理时钟中发挥着双重作用.
祖先的昼夜钟基因可能已经进化为跨越多个时期的功能,适应不同的发育背景.
这表明昼夜钟机制的进化路径比以前假设的更为灵活.

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