低剂量GBCA用于脑瘤的使用 动态对比增强MRI:可行性研究
Daniel Lewis1,2,3,4, Ka-Loh Li5,6, Mueez Waqar7,5,8
1Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. dan.lewis1112@gmail.com.
Scientific reports
|February 28, 2024
概括
这项研究引入了一种用于脑成像的新低剂量动态对比增强MRI协议. 该技术准确地绘制出动力参数,使用较少的基于加多的对比剂 (GBCA).
科学领域:
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 动态对比增强 (DCE) MRI对于脑瘤分析至关重要.
- 目前的DCE-MRI协议通常需要高剂量的基于加多的对比剂 (GBCAs).
- 减少GBCA剂量对于患者的安全性和成本效益至关重要.
研究的目的:
- 开发和评估一种新的低GBCA剂量协议,用于大脑DCE-MRI中高空间分辨率的动力参数映射.
- 评估这个新协议的可行性和准确性.
主要方法:
- 在1.5T时对19名头内基瘤患者进行前性成像.
- 使用了一次注射,低剂量,双时间分辨率交错的DCE-MRI采集.
- 通过蒙特卡洛模拟和体内比较与全剂量协议和体内病理学评估动力参数 (ve,Ktrans,vp).
主要成果:
- 与高空间,低时间分辨率方法相比,低剂量交叉协议显示出更高的准确性.
- 来自低剂量方案的动力参数与全剂量获取结果显著相关 (p < 0.001).
- 该协议还显示了与微血管密度标志物 (p <0.05) 的显著关联.
结论:
- 在大脑DCE-MRI中精确的高空间分辨率动态参数映射在显著降低GBCA剂量时是可行的.
- 这种低剂量方案为更安全,更容易获得的脑瘤成像提供了一个有希望的替代方案.
- 需要在更大的队列中进一步验证.
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