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肝脏线粒体的空间地图揭示了由营养感应信号形成的功能异质性

Sun Woo Sophie Kang1, Rory P Cunningham1, Colin B Miller1

  • 1Cell Biology and Imaging Section, Thoracic and GI Malignancies Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.

Nature communications
|February 28, 2024
PubMed
概括

肝脏线粒体根据它们的位置表现出不同的功能,周边线粒体有利于β-氧化和周边线粒体支持脂质合成. 这种空间组织由营养感知通路和蛋白质酸化调节,这对肝脏稳态至关重要.

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