对不同胃病患者的Helicobacter pylori耐药性的分析
Yongfu Shao1,2, Yifan Lin3, Ziyi Fang1,2
1Health Science Center, Ningbo University, Ningbo, 315211, China.
Scientific reports
|February 28, 2024
概括
杆菌 (H. pylori) 的抗生素耐药性是治疗失败的主要原因之一. 这项研究发现,缩性胃炎,老年和使用质子抑制剂 (PPI) 会增加H. pylori耐药感染的风险.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- Helicobacter pylori (H. pylori) 的抗生素耐药性是一个重大的全球健康问题,直接影响了根除成功率.
- 了解区域和特定疾病的耐药性模式对于有效的H. pylori治疗策略至关重要.
- 有限的数据存在于H. pylori在各种胃粘膜病变中的抗生素耐药性.
研究的目的:
- 分析H. pylori抗生素耐药性趋势和个人资料,与患者人口统计和胃病相关.
- 为了研究质子抑制剂 (PPI) 史对H. pylori抗生素耐药性的影响.
- 开发一种临床H. pylori抗生素耐药性风险的预测模型.
主要方法:
- 这是一项长达8年的回顾性队列研究,涉及2847名患者.
- 对H.pylori对阿莫西西林 (AMX),克拉里胺素 (CLR),勒沃素 (LVX) 和法拉佐利 (FR) 的耐药性率的分析.
- 评估单药和多药耐药性模式,以及与胃病变,年龄,性别和PPI使用的关联.
主要成果:
- 整体阻力率:AMX 8.18%,CLR 38.11%,LVX 43.98%,FR 13.73%. 这是一个很大的问题.
- 单抗,双抗,三抗和四抗的阻力率分别为30.17%,25.96%,6.46%和0.63%.
- 在过去5年观察到的单抗和多抗下降趋势;缩性胃炎,年龄较大和PPI史被确定为耐药H. pylori感染的高风险因素.
结论:
- 性胃炎是高风险H. pylori抗生素耐药性的关键临床指标.
- 患者的年龄,性别,胃病变类型和最近的PPI治疗史与H. pylori抗生素耐药性有关.
- 这些发现凸显了缩性胃炎患者中耐药H. pylori感染的风险增加,PPI使用史和年龄较大.
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