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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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在CRL5-SPSB3无酸酶的核cGAS降解目标

Pengbiao Xu1, Ying Liu1,2, Chong Liu1

  • 1Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.

Nature
|February 28, 2024
PubMed
概括

在循环细胞中,ubiquitin蛋白质体系统降解核循环GMP-AMP合成酶 (cGAS). 这种由SPSB3蛋白调节维持平衡,并可作为增强抗病毒防御的目标.

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