慢性病患者的长期臭氧暴露和死亡率:一项大型队列研究
Ejin Kim1,2, Hyuk Huh3,4, Yongwon Mo5
1Institute of Health and Environment and Graduate School of Public Health, Seoul National University, Room 708, Building 220, Gwanak-Ro Gwanak-Gu, Seoul, 08826, Republic of Korea.
BMC nephrology
|February 28, 2024
概括
对环境臭氧 (O3) 的长期暴露显著增加了慢性病 (CKD) 患者末期病 (ESRD) 和全因死亡率的风险. 减少臭氧排放可以改善公共卫生和环境质量.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 关于长期臭氧 (O3) 暴露影响的流行病学研究对慢性病 (CKD) 产生了不确定的结果.
- 环境臭氧对CKD进展和死亡率的具体影响尚不清楚.
研究的目的:
- 调查长期环境臭氧暴露与慢性病患者末期病 (ESRD) 风险和全因死亡率之间的关联.
主要方法:
- 利用考克斯比例危险模型与61,073名参与者评估臭氧对ESRD和死亡率的影响.
- 在入学前一年对臭氧暴露进行插值时使用的逆距离权重 (IDW).
- 调整为社会经济地位和其他污染物在两个污染物模型.
主要成果:
- 单一污染物模型显示,臭氧与ESRD风险增加和全因死亡率之间存在显著的关联.
- 在两种污染物模型中,二氧化并没有减弱观察到的臭氧效应.
- 臭氧暴露的危险比率表明ESRD和全因死亡率的风险增加,区级和个人地址评估的值各不相同.
结论:
- 长期暴露于环境臭氧与CKD患者ESRD和死亡率的风险增加有关.
- 旨在减少臭氧排放的战略对于公共卫生和环境效益至关重要.
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