胎儿大脑生长和婴儿自闭症特征
Ezra Aydin1,2,3, Alex Tsompanidis4, Daren Chaplin5
1Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. ea3013@cumc.columbia.edu.
Molecular autism
|February 28, 2024
概括
使用超声波的胎儿大脑测量,包括头周长和横脑直径,与幼儿的自闭症特征相关. 这些产前生长指标可以在怀孕20周的早期被检测出来.
科学领域:
- 神经发育障碍 神经发育障碍
- 自闭症谱系障碍 (ASD) 研究研究
- 产前诊断 在产前诊断
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是大脑结构上的差异.
- 有限且不一致的研究存在于胎儿大脑生长和后来的婴儿自闭症特征.
- 以前的研究经常使用胎儿头周长 (HC) 作为大脑发育的间接衡量标准.
研究的目的:
- 调查胎儿子区域大脑测量与幼儿自闭症特征之间的相关性.
- 探索与自闭症相关的神经发育轨迹的早期指标.
- 为了确定产前超声波测量是否可以预测以后的自闭症特征.
主要方法:
- 招募了219名孕妇 (104名男性,115名女性) 进行二维超声波.
- 测量胎儿头周长 (HC),腹腔大心脏 (VA) 和跨大脑直径 (TCD) 在怀孕12,20周和26-30周.
- 在18至20个月的179名婴儿中使用幼儿自闭症定量检查表 (Q-CHAT) 评估了自闭症特征.
主要成果:
- 小孩的Q-CHAT得分显示,在怀孕20周时,与跨大脑直径 (TCD) 有积极的关联.
- 怀孕28周Q-CHAT得分也与头周长 (HC) 有积极关联.
- 这些关联在多重回归模型中仍然显著,控制性别,产妇年龄和出生体重.
结论:
- 通过超声波评估产前大脑生长,与在幼儿中观察到的自闭症特征有关.
- 特定的胎儿大脑测量,如TCD和HC,可以作为早期指标.
- 从怀孕20周开始,对胎儿大脑发育的潜在自闭症相关特征进行超声波评估是可行的.
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