肠道微生物组的变化与婴儿皮炎的严重程度有关
Xiaoyi Liu1, Meiqin Cai2, Meiru Chen3
1Department of Dermatology, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The Australasian journal of dermatology
|February 29, 2024
概括
婴儿肠道微生物,如Clostridium sensu stricto和Parabacteroides,与阿托皮炎 (AD) 的严重程度有关. 特定的细菌变化和代谢途径与阿尔茨海默病的严重程度相关,并影响生活质量.
科学领域:
- 微生物组研究的研究.
- 儿科皮肤学 儿科皮肤学
- 肠 - 皮肤轴
背景情况:
- 亚托邦性皮肤炎 (AD) 在婴儿中很常见,其发展与肠道微生物失调有关.
- 与阿尔茨海默病相关的早期肠道微生物组的具体变化及其严重程度仍未得到充分研究.
研究的目的:
- 为了研究不同严重程度的亚托皮性皮炎 (AD) 的婴儿的肠道微生物组成和功能概况.
- 为了确定与AD严重程度相关的特定微生物和功能变化.
主要方法:
- 六十二名患有阿尔茨海默病的婴儿被分为轻度,中度和重度的组,这些组的分类是基于Scoring Atopic Dermatitis (SCORAD) 指数.
- 用16S核糖体RNA基因测序分析了肠道微生物的组成和功能.
- 进行了生活质量调查问卷,以评估儿童和家庭的福祉.
主要成果:
- 严重的AD婴儿与轻度的AD婴儿相比,显示了Clostridium sensu stricto和Collinsella的减少,并增加了Parabacteroides.
- 斯科拉德指数与细菌类丰富性和脂/糖脂代谢途径正相关.
- SCORAD指数与Clostridium sensu stricto丰度负相关,与生活质量影响正相关.
结论:
- 不同的肠道微生物组成和功能途径与婴儿的AD严重程度有关.
- 酸盐产生细菌 (Clostridium sensu stricto) 和脂生成细菌 (Parabacteroides, Bacteroides) 的变化与AD的严重程度有关.
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