对ASD患者肠道微生物组的综合多样性分析:从α,β到玛多样性
Hongju Daisy Chen1,2, Lianwei Li1,2, Fubing Yu3
1Computational Biology and Medical Ecology Lab, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
FEMS microbiology letters
|February 29, 2024
概括
自闭症谱系障碍 (ASD) 肠道微生物群的多样性显示出复杂的模式. 虽然在一些自闭症病例中,α-多样性可能会增加,但β-多样性和玛-多样性指标表明微生物群落发生了变化,特别是影响了罕见物种.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 遗传学和基因组学 遗传学和基因组学
背景情况:
- 自闭症谱系障碍 (ASD) 影响全球1%的儿童,原因尚不清楚.
- 肠道微生物组的改变与ASD相关的行为有关.
- 现有的关于ASD-微生物组联系的研究缺乏共识.
研究的目的:
- 综合分析ASD个体肠道微生物组的多样性变化.
- 调查与ASD相关的alpha,beta和gamma多样性指标.
- 探索罕见与主导物种对ASD-微生物组关系的影响.
主要方法:
- 对8个已发表的数据集 (16S rRNA测序) 的元分析.
- 包括898个ASD样本和467个健康对照 (HC).
- 希尔数的应用用于跨稀有性-常见性-主导性频谱的多样性测量.
主要成果:
- 在约1/3的研究中,阿尔法多样性在ASD中高于HC,与多样性-疾病关系 (DDR) 猜测保持一致.
- 在50-75%的病例中,β多样性支持了安娜·卡列尼娜原则 (AKP),表明ASD的微生物组不同.
- 马多样性分析表明,ASD的多样性区域规模较大,与AKP一致,但MAD和RIP参数没有显著差异.
结论:
- 在ASD中肠道微生物群的多样性是复杂的,并不总是单调的.
- 在罕见的微生物物种中,ASD和HC之间的差异更加明显.
- 需要进一步的研究来解决不一致性,并了解ASD-微生物组的相互作用.
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