在犬慢性病中对白蛋白尿的综合分析

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Updated: Jul 2, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Karel Paukner^1,2, Zita Filipejova¹, Jan Mareš³

¹Small Animal Clinic, University of Veterinary Sciences Brno, Brno, Czech Republic.

Veterinary medicine and science

|February 29, 2024

概括

尿中的白蛋白与肌素比率 (UAC) 与狗的病标志物有很强的相关性. 这一比率是检测功能障碍和蛋白尿在犬慢性病 (CKD) 的有希望的工具.

科学领域:

兽医医学兽医医学兽医医学
腎臟病學 (nephrology) 是一種醫學.
生物化学生物化学

背景情况:

白蛋白尿是慢性病 (CKD) 的关键指标,但在检测方面未得到充分利用.
狗的白蛋白尿,生化参数和血压之间的关系还不清楚.

研究的目的:

评估白蛋白尿与狗中CKD标志物和高血压的关系.
评估尿动白蛋白与肌素比率 (UAC) 和尿动蛋白与肌素比率 (UPC) 之间的相关性.
确定UAC对查犬类CKD的实用性.

主要方法:

追溯分析了102只根据疾病状态分类的狗.
确定UAC,UPC,生物化学,血液学,年龄和缩血压.
统计分析包括皮尔森相关系数和接收器运行特征 (ROC) 曲线分析.

主要成果:

在UAC和UPC比率之间发现了强烈的正相关性 (r = 0.902).
与健康对照相比,患有早期和慢性CKD的狗的中位数UAC值显著更高.
10毫克/克的UAC值显示了对功能受损的高灵敏度 (81.8%) 和特异性 (89.4%).
UAC与SDMA有显著的相关性 (r=0.566) 并在高血压犬中升高.

结论:

在功能受损和正常的狗之间,UAC显著不同.
UAC和UPC之间的高相关性支持其在蛋白尿评估中的使用.
在狗中,UAC显示为蛋白尿和功能改变的诊断标志物.

关键词:

专辑蛋白尿症是什么意思狗类犬类动物狗类犬类慢性脏疾病慢性脏疾病这种高血压,高血压.蛋白质尿症是一种蛋白质尿症.脏生物标志物脏生物标志物

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